Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 28;10:593383. doi: 10.3389/fonc.2020.593383

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Monti, Menichini, Speciale, Cutrona, Fais, Taiana, Neri, Bomben, Gentile, Gattei, Ferrarini, Morabito and Fronza

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

(A) Domain organization of P53 protein (TAD, transactivation domain; PRD, proline-rich domain; DBD, DNA-binding domain; NLS, nuclear localization signal; OD, oligomerization domain; CTD, C-terminal domain) and distribution of TP53 missense mutations from the cBioPortal online tool (TCGA) (8, 9). Missense mutations location (green signs) throughout the P53 protein is shown according to the frequency and the position of the amino acid hit. (B) Heterogeneity of mutants P53 with examples of the corresponding TP53 mutations.