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. 2020 Nov 10;10:19471. doi: 10.1038/s41598-020-76570-9

Figure 3.

Figure 3

Differentially abundant genera identified among 46 participants receiving outpatient addiction treatment, 2016–2017. We used ALDEx2 to identify nine genera that were differentially abundant between participants who used opioid agonists (Ag) vs. participants who used neither agonists nor antagonists (N). Differentially abundant genera had false discovery rate (FDR) corrected p values < 0.05 for Wilcoxon rank sum tests comparing centered log ratios (a) computed from genera abundance (sample profiles are plotted as columns in heatmaps, rows represent the nine taxa). The corresponding relative abundance of each taxa is shown in (b). Clostridium cluster XIVa (FDR p value: 0.033), unclassified Enterobacteriaceae (FDR p value: 0.026), Lactobacillus (FDR p value: 0.031), Faecalicoccus (FDR p value: 0.037), Anaerostipes (FDR p value: 0.040), and Streptococcus (FDR p value: 0.045) abundances were higher in Ag vs. N participants while Roseburia (FDR p value: 0.043), unclassified Firmicutes (FDR p value: 0.031), and Bilophila (FDR p value: 0.037) were less abundant in Ag vs. N participants. We found no statistically significant differences between other opioid agonist/antagonist groups. Ag agonist only, AgAt agonist–antagonist, At antagonist only, N neither agonist nor antagonist.