Figure 5.
SidD deficiency attenuates the virulence of S. apiospermum in a murine model of disseminated scedosporiosis. (A) Survival of cyclophosphamide/fluorocytosine-treated mice infected with the indicated S. apiospermum strains (2 x 103 CFU/animal). Data were obtained from a total of 9 mice infected per strain. For visibility, the percent surviving was indicated at day 18 for the animals inoculated with the sidD mutant strain M2. Statistical differences for mouse survival were calculated using the Log-Rank test. (B) Tissue burden in kidneys of cyclophosphamide/fluorocytosine-treated mice infected with the indicated strains, as revealed by determination of the fungal load (in CFUs/g) 6 days post-infection (n = 5). Dark dots correspond to animals euthanatized 5 days post-infection. Horizontal lines indicate median values.