FIGURE 2.

IL-4Rα-/- mice exhibit reduced susceptibility to DSS-induced colitis. Colitis was induced in WT and IL-4Rα-/- mice by daily treatment with a 3% DSS solution in the drinking water for seven days. (A) Macroscopic photographs of colons and (B) colon length measurements are shown. The data are presented as the mean ± SEM values for eight mice and are representative of one of three independent experiments. **p < 0.01; ***p < 0.001. (C) Representative images of H&E staining are shown. The scale bar represents 100 µm. (D) Histological scoring of DSS-induced colitis is shown. The data are presented as the mean ± SEM values for four to six mice. ***p < 0.001.