Table IV.
IDH1 compound mutation status in brain tumors of Saudi Arabian population analyzed by next-generation sequencing.
| Serial number | Lab code | Sex | Age, years | Diagnosis | IDH1 | Exon | Allele frequency, % | Phred score | Coverage | P-value | IDH2 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | HALK-45 | F | 38 | Gliosarcoma | c.395G>A; p. (Arg132His) | 4 | 5.01 | 242.779 | 1996 | 0.00001 | NEG |
| 2 | HALK-45 | F | 38 | Gliosarcoma | c.315C>T; p. (Gly105Gly) | 4 | 30.18 | 5818.57 | 1998 | 0.00001 | NEG |
| 3 | HALK-48 | M | 68 | GBM | c.395G>A; p. (Arg132His) | 4 | 3.66 | 113.809 | 1995 | 0.00001 | NEG |
| 4 | HALK-48 | M | 68 | GBM | c.315C>T; p. (Gly105Gly) | 4 | 33.35 | 6742.06 | 1994 | 0.00001 | NEG |
| 5 | HALK-39 | M | 55 | Low grade glioma | c.369A>G; p. (Gly123Gly)a | 4 | 5.26 | 119.741 | 1998 | 0.00001 | NEG |
| 6 | HALK-39 | M | 55 | Low grade glioma | c.315C>T; p. (Gly105Gly) | 4 | 4 | 143.241 | 2000 | 0.00001 | NEG |
| 7 | 84-N | M | 9 | Pilocytic astrocytoma | c.395G>A; p. (Arg132His) | 4 | 18.82 | 2798.99 | 1998 | 0.00001 | NEG |
| 8 | 84-N | M | 9 | Pilocytic astrocytoma | c.368G>A; p. Gly123Glu) | 4 | 3 | 65.2141 | 2000 | 0.00001 | NEG |
| 9 | KAMC-27 | M | 42 | GBM | c.395G>A; p. (Arg132His) | 4 | 20.92 | 2191.56 | 1319 | 0.00001 | NEG |
| 10 | KAMC-27 | M | 42 | GBM | c.394G>A; p. (Arg132Ser) | 4 | 33.75 | 6868.22 | 1994 | 0.00001 | NEG |
| 11 | HALK-44 | F | 27 | Anaplastic oligodendroglioma | c.315C>T; p. (Gly105Gly) | 4 | 43.57 | 10052 | 1997 | 0.00001 | NEG |
| 12 | HALK-44 | F | 27 | Anaplastic Oligodendroglioma | c.395G>A; p. (Arg132His) | 4 | 36.95 | 7849.08 | 1992 | 0.00001 | NEG |
| 13 | 92-N | F | 8 | PNET | c.709T>C; p. (Ser237Pro)a | 5 | 47.22 | 472.971 | 108 | 0.00001 | NEG |
| 14 | 92-N | F | 8 | PNET | c.395G>A; p. (Arg132His) | 4 | 0.79 | 21.675 | 252 | 0.0068 | NEG |
| 15 | HALK-27 | M | 59 | GBM | c.414+9T>Aa | Intronic | 70.93 | 384.357 | 86 | 0.00001 | ND |
| 16 | HALK-27 | M | 59 | GBM | c.395G>A; p. (Arg132His) | 4 | 49 | 809.429 | 400 | 0.00001 | ND |
| 17 | 77-N | M | 14 | Astrocytoma | c.414+9T>Aa | Intronic | 85.29 | 221.041 | 34 | 0.00001 | ND |
| 18 | 77-N | M | 14 | Astrocytoma | c.395G>A; p. (Arg132His) | 4 | 42.5 | 69.0889 | 40 | 0.00001 | ND |
| 19 | KAMC-39 | F | 39 | Oligoastrocytoma | c.395G>A; p. (Arg132His) | 4 | 6.41 | 411.865 | 1996 | 0.00001 | NEG |
| 20 | KAMC-39 | F | 39 | Oligoastrocytoma | c.315C>T p. (Gly105Gly) | 4 | 6.21 | 384.588 | 1998 | 0.00001 | NEG |
| 21 | 54-N | F | 14 | Medulloblastoma | c.380C>T; p. (Pro127Leu) | 4 | 3.97 | 45.0045 | 1992 | 0.00003 | NEG |
| 22 | 54-N | F | 14 | Medulloblastoma | c.315C>T p. (Gly105Gly) | 4 | 34.1 | 4605.54 | 2000 | 0.00001 | NEG |
a
Novel mutation. IDH, isocitrate dehydrogenase; GBM, glioblastoma; WHO, World Health Organization; M, male; F, female; ND, not done; NEG, negative.