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. 2020 Oct 29;20(6):388. doi: 10.3892/ol.2020.12251

Figure 1.

Figure 1.

Expression pattern of circ_0008450 in the tissues and serum of patients with HCC and HCC cells. RT-qPCR was performed to detect the (A) expression of circ_0008450 in 30 paired HCC tissues and adjacent normal HCC tissues and to analyze the (B) expression of circ_0008450 in serum of patients with HCC and healthy controls. (C) ROC analysis was used to assess the diagnostic value of circulating circ_0008450 for differences between patients with patients and healthy controls. (D) RT-qPCR was conducted to analyze circ_0008450 expression levels in THLE-2, SNU-387 and Huh7 cells (*P<0.05 vs. THLE-2 cells) and to assess the relative expression of circ_0008450 and CMTM3 in Huh7 cells with (E) actinomycin D or (F) RNase R treatment. (G) The expression of circ_0008450 and CMTM3 were measured by RT-qPCR using oligo(dt)18 primers or random primers. *P<0.05. circ, circular; HCC, hepatocellular cancer; CMTM3, CKLF-like MARVEL transmembrane domain containing 3; RT-qPCR, reverse transcription-quantitative PCR; ROC, receiver operating characteristic curve; AUC, area under the curve.