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. 2020 Oct 29;20(6):391. doi: 10.3892/ol.2020.12254

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Copyright: © Cai et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Effects of TST and miR-216b on cell cytotoxicity and apoptosis. (A) Effect of TST on U2OS and MG63 cell (A) cytotoxicity, (B) FoxM1 mRNA expression and (C) miR-216b expression. (D) miR-216b expression levels following transfection with miR-216b mimic or mimic-NC. The effects of TST (1 µM) and miR-216b mimic on U2OS and MG63 cell (E) cytotoxicity of miR-216b and TST treatment in normal and cancer cells; and (F) apoptosis. (G) Relationship between TST concentration and its potency. The combined effect of TST (1 µM) and miR-216b mimic on U2OS and MG63 cell cytotoxicity. *P<0.05, **0.05≤P<0.01. TST, thiostrepton; miR, microRNA; FoxM1, forkhead box M1; NC, negative control; NS, not significant.