Figure 4.

(A) Coefficient of each prognostic miRNA obtained by Cox regression analysis. Heatmap shows the expression data of the six miRNAs used for the miRscore construction in the training (B) and validation cohort (C). Columns represent patients who were sorted descendingly according to their miRscore levels. (D) Determination of the cutoff point (-5.83) for miRscore in prognosis analysis with overall survival as the outcome parameter. Distribution of the miRscore in the training (E) and validation patients (F). The x-axis represents patients. The intersection point of black and yellow dotted line represents the miRscore cutoff classifying patients into high and low subgroups. (G, H) Covariate tracks show the clinical attributes of each patient in the training and validation cohort, respectively. Red boxes indicate that the miRscore group is enriched for the indicated attribute (P < 0.05, Chi-square test). miRscore, microRNA risk score.