Table 1.

Overview of modern algorithms with characteristics

Algorithm*	Components†	Sample‡	Base rate (%)	Sensitivity (%)§/specificity (%)¶
ROMA, 2009 USA7	CA125, HE4, menopause	352 Benign 179 OC	33.7	74.7/92.3
CPH-I, 2015 International9	CA125, HE4, age	809 Benign 246 OC	23.3	95.0/78.4
R-OPS, 2016 Thailand10	CA125, HE4, menopause, ultrasound	158 Benign 102 OC	39.2	93.9/79.9

Benign=benign tumors. OC=Ovarian cancer incl borderline tumors. For CPH-I and R-OPS, the development samples were used.

*Algorithm abbreviation, year of publication, country, and reference.

†Components of the algorithm.

‡Samples of pelvic masses.

§Sensitivity of ovarian cancer identified according to the algorithm.

¶Specificity of benign tumors identified according to the algorithm.

CA125, Cancer antigen 125; CPH-I, Copenhagen Index; HE4, human epididymis protein 4; OC, ovarian cancer, including borderline tumors; ROMA, Risk of Malignancy Algorithm; R-OPS, Rajavithi–Ovarian Predictive Score.