Figure 1.
TRC-794 decreases cell viability and induces apoptosis.
(A) MTT cell viability assay against increasing concentrations of the SMAP TRC-794 after 24hr incubation. All measurements are normalized to DMSO control. (B) Annexin V staining of cells treated with DMSO, 100uM Z-VAD (caspase inhibitor), TRC-794, or a combination of Z-VAD + TRC-794 after 24hrs. Annexin V staining in the A549 control and Z-VAD groups was barely detectable. The means ± SD across 3 independent replicates are reported.