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. 2020 Nov 10;10:19416. doi: 10.1038/s41598-020-76375-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Association between the number of Nef HLA-associated adapted polymorphisms and plasma viral load. (A) Results of regression analysis between the total number of HLA-adapted Nef amino acid variants and log10-transformed plasma viral load (pVL) in chronically HIV-1 subtype B infected subjects in Japan (n = 375). (B) Regression coefficient and 95% CI obtained from the regression analysis in which pVL and the number of HLA-adapted Nef variants were used as dependent and independent variables for HLA-matched subjects. (C) Difference in plasma viral load between the subjects harbouring HLA-adapted Nef 120F and 125H mutations regardless of the HLA class I alleles expressed by the subject. Statistical analysis was performed by using the Mann–Whitney U-test. n.s. not significant.