Fig. 1. Schematic of the study and sample distributions.

a Schematic of the study. Patients in cohort 3 were referred to genome-guided clinical trials when meeting criteria. b Purpose of the three different investigated cohorts. c Treatment information. ^†Clinical trial. ^‡Fudan Umbrella Trial. dd dose densed, EC epirubicin + cyclophosphamide, P paclitaxel, T docetaxel, NE vinorelbine + epirubicin, PE paclitaxel + epirubicin, CbP carboplatin, AI aromatase inhibitor. d Clinical features of our prospective cohort compared with those found in previous sequencing studies of breast cancers (MSKCC and TCGA). Source data for d are provided as a source data file.