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. 2020 Nov 10;10:19488. doi: 10.1038/s41598-020-74929-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heterothermic naked mole-rats (NMRs; Heterocephalus glaber) possess thermogenic brown adipose tissue (BAT). (a) Photograph of an adult NMR. (b) Anatomical (top), hematoxylin–eosin (HE)-stained (middle) and cell (bottom) images of light BAT (lBAT) and dark BAT (dBAT). Scale bar = 100 µm for HE-stained images, 25 µm for insets, 200 µm for cell images. (c) BAT and rectum temperatures of anesthetized NMRs before and after the i.p. injection of 1 mg/kg noradrenaline (arrow) at 30 °C (n = 3 animals). *p < 0.05 significantly different from each temperature at 9 min (paired t-test). (d) Positron emission tomography/computed tomography (PET/CT) imaging of NMR-BAT after the injection of 1 mg/kg noradrenaline and 11 MBq 2-deoxy-2-[¹⁸F]fluoro-d-glucose ([¹⁸F]FDG) at 32 °C. (e) In vitro oxygen consumption rates of isolated adipocytes after the injection of 1 µM noradrenaline (dotted line) with or without pre-incubation with 10 µM SR59230A (n = 3 animals per treatment). *p < 0.05 significantly different from SR59230A treated cells (paired t-test). All data are presented as means ± SEM with the exception of (c), which are means ± SD.