Table 4.

Cox multivariable analysis.

Variable	HR	95% CI	p-Value
Age ≥ 50 years	1.61	0.39–6.66	0.513
Stage III or IV	10.93	2.48–48.04	0.002
Histological grade 3	2.18	0.24–3.60	0.091
LVSI (+)	1.91	0.51–7.18	0.340
N1	0.45	0.13–1.61	0.220
M1	4.68	1.57–14.01	0.006
CLDN6-high	3.50	2.42–9.43	0.014

HR, hazard ratio; CI, confidence interval. LVSI, lymphovascular space involvement; N1, positive for lymph node metastasis; M1, positive for distant metastasis.