Figure 2.

(A) Illustration of the stimuli responsive drug release from Doxo/PheoA-MNPs under near-infrared (NIR) irradiation (red ball = Pheophorbide A, green ball = Doxorubicin). (B) UV-Vis spectra of MNPs (black), PheoA-MNPs (red) and free Doxo (blue). (C) The cumulative drug release from Doxo/PheoA-MNPs triggered by NIR irradiation at a power density of 2 W/cm² for different times in phosphate-buffered saline (PBS) (pH 7.4). (D) Thermal images of MNP aqueous solution during (left) ON and (right) OFF cycles. (E) Temperature change of MNP solutions with varying concentrations (0–200 μg/mL) for a period of 20 min under exposure of 808 nm NIR light (1.2 W/cm²). (F) Temperature evaluation of MNPs over four laser ON/OFF cycles (laser ON time: 10 min, laser OFF time: 10 min). (G) Thermal images of tumor-bearing mouse that was exposed to laser irradiation at 808 nm (white dotted circle indicates tumor area) and (H) the local temperature change of the MNPs in the tumor.