Table 1. Baseline recipient, donor, peri and post-operative.
| Characteristics | Outcome |
|---|---|
| Recipient characteristics | |
| N | 454 |
| Age (years), median (range) | 48 (16–70) |
| Male gender | 232 (51.1%) |
| Diagnosis (all) | |
| CF | 147 (32.4%) |
| EMP | 132 (29.1%) |
| PPH | 27 (5.9%) |
| IPF | 90 (19.8%) |
| Other | 58 (12.8%) |
| ICU admission pre-operative | 43 (9.5%) |
| mPAP >25 mmHg | 235 (51.8%) |
| Waitlist time (days), median (range) | 150 (0–1,965) |
| Charlson-Deyo Comorbidity index (12), median (range) | 1 (0–4) |
| 2 | 125 (27.5%) |
| 3 | 45 (9.9%) |
| 4 | 16 (3.5%) |
| 5 | 3 (0.7%) |
| Donor characterisics | |
| Age (years), median (range) | 45 (11–85) |
| Charlson-Deyo index (12), median (range) | 0 (0–5) |
| 1 | 42 (9.3%) |
| 2 | 7 (1.5%) |
| 3 | 5 (1.1%) |
| 4 | 5 (1.1%) |
| 5 | 1 (0.2%) |
| Cause of death | |
| Cranial bleeding/ischemia | |
| Traumatic | 165 (36.3%) |
| Atraumatic | 230 (50.7%) |
| Asphyxiation | 51 (11.2%) |
| Other | 8 (1.8%) |
| CMV mismatch | 122 (26.9%) |
| Extended criteria according to ISHLT (1) | |
| Age ≥55 years | 128 (28.2%) |
| Smoking history ≥20 packyears | 77 (17.0%) |
| Chest X-Ray pathologic | 122 (26.9%) |
| Bronchoscopy pathologic | 50 (11.0%) |
| PaO2-FiO Ratio <300 mmHg | 171 (37.7%) |
| Number, median (range) | 1 (0–4) |
| 1 | 161 (35.5%) |
| 2 | 123 (27.1%) |
| 3 | 39 (8.6%) |
| 4 | 6 (1.3%) |
| Peri and post-operative characteristics | |
| Unilateral transplantation | 36 (7.9%) |
| Retransplantation | 19 (4.2%) |
| ECMO use | 186 (41.0%) |
| Donor cardiac after circulatory death | 16 (3.5%) |
| Max. ischemic time (minutes), median (range) | 334 (132–885) |
| ICU time (days), median (range) | 4 (1–311) |
| PGD Grade3 at 72 hours | 75 (16.5%) |
PGD, primary graft dysfunction; CMV, Cytomegalovirus; ICU, intensive care unit; ECMO, extracorporal membrane oxygenation; mPAP, mean pulmonary artery pressure; CF, cystic fibrosis; IPF, interstitial pulmonary fibrosis; PPH, primary pulmonary hypertension; EMP, emphysema.