Figure 1.

Disruption of cadherin-catenin complex in MPA of lung. (A) Cancer tissues of the MPA and lepidic groups were applied with H&E staining and IHC staining to show expression or the intracellular distribution of the three key molecules which compose the cadherin-catenin complex (E-cadherin, α-catenin and β-catenin). The pictures were taken under 400× power phase microscopically. Red arrows indicated typical negative tumor cells in the MPA group and the green ones indicated typical positively stained tumor cells in the lepidic group. (B) For each slide from both groups, the TPS of E-cadherin and α-catenin were calculated by counting the positive rate of tumor cells in each 10 views at 400× power phases under microscope. Any convincing membrane staining of the cancer cells were considered to be positive. The data were then analyzed by application of two-tailed unpaired student’s t-tests. ***, indicated significant difference (P<0.0001). H&E, hematoxylin and eosin; IHC, immunohistochemistry; MPA, Micropapillary-predominant adenocarcinoma; TPS, tumor positive score.