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The immune suppression of Tregs via trans-endocytosis of CD80/86 from APCs. Upon activation by the combination of CTLA-4: CD80/86, Tregs will endocytose CD80/86 on the surface of antigen presentation cells (APC), the binding receptor of the costimulatory receptor CD28 on naïve T cells. Therefore, the activated pathway of naïve T cells is blocked.
