Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 11;20:826. doi: 10.1186/s12879-020-05522-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — Transmission electron microscopy showing the infection stages of isolated A. phagocytophilum KZ_A3-infected HL-60 cells. Adhesion, replication, invasion, and release stages of the isolated A. phagocytophilum within HL-60 cells (a-d). Representative images of dense-cored cells and reticulate cells; the large arrow indicates a dense nucleoid and a ruffled outer membrane, and the spheroid indicates individual dense-cored cells surrounded by a membranous projection (c). Scanning electron micrograph of a cluster of isolated A. phagocytophilum KZ_A3 within HL-60 cells (e, f) A. phagocytophilum KZ_A3 were observed to replicate in a large vesicle inside the cell. Here, the vesicle has ruptured, revealing A. phagocytophilum (c–d, 20000x)