Table 2.
Clinical features of participants and comparison of slow and fast resolvers
| All participants (n = 13) | Slow resolvers (n = 5) |
Fast resolvers (n = 8) |
P value | |
|---|---|---|---|---|
| Mean age—year (range) | 51.5 (29–75) | 51.8 (29–67) | 51.4 (33–75) | |
| Female sex—number (%) | 7 (54%) | 3 (60%) | 4 (50%) | |
| Race—number (%) | ||||
| White | 9 (69%) | 4 (80%) | 5 (63%) | |
| African American | 2 (15%) | 0 (0%) | 2 (25%) | |
| Other | 2 (15%) | 1 (20%) | 1 (13%) | |
| Smoking—number (%) | ||||
| Active | 5 (38%) | 2 (40%) | 3 (38%) | |
| Former | 4 (31%) | 2 (40%) | 2 (25%) | |
| Never | 4 (31%) | 1 (20%) | 3 (38%) | |
| BMI—kg/m2 (range) | 27.1 (15.6–38.8) | 25.4 (16.9–34.6) | 29.2 (15.6–38.8) | |
| ARDS etiology—number (%) | ||||
| Viral pneumonia | 6 (46%) | 3 (60%) | 3 (38%) | |
| Bacterial pneumonia | 1 (8%) | 1 (20%) | 0 (0%) | |
| Aspiration | 2 (15%) | 1 (20%) | 1 (13%) | |
| Idiopathic | 3 (23%) | 0 (0%) | 3 (38%) | |
| Vaping | 1 (8%) | 0 (0%) | 1 (13%) | |
| PAO2/FiO2—ratio (range) | 135.5 (66–250) | 109.2 (67–162) | 151.9 (66–250) | |
| Proned—number (%) | 1 (8%) | 1 (20%) | 0 (0%) | |
| Paralyzed—number (%) | 5 (38%) | 4 (80%) | 1 (13%) | |
| Charlson Comorbidity Index—mean (range) | 3.4 (0–7) | 3 (0–6) | 4 (2–7) | |
| SOFA—mean (range) | 10.2 (6–15) | 10.2 (6–14) | 10.1 (8–15) | |
| Apache II—mean (range) | 21.2 (13–29) | 22.6 (17–29) | 20.3 (13–28) | |
| Days to extubation—mean (range) | 10.5 (1–59) | 21.4 (8–59) | 3.75 (1–6) | 0.0016 |
Age, BMI, PAO2/FiO2, Sequential Organ Failure Assessment (SOFA), Apache II, and days to extubation presented the mean value with ranges represented in parentheses. P-values compare the slow and fast resolvers using the Mann Whitney rank-sum test