Table 3.
Blood pressure and rates of hypertension in adulthood by MTHFR genotype
| MTHFR genotype | ||||
|---|---|---|---|---|
| CC | CT | TT | P valueb | |
| Total cohort (up to 90 years) | n = 2635 | n = 2606 | n = 719 | |
| Age, years | 68.9 (68.3, 69.5) | 69.0 (68.4, 69.6) | 68.6 (67.5, 69.7) | 0.806 |
| Systolic BP, mmHg | 140.7 (139.8, 141.5) | 141.5 (140.8, 142.4) | 141.1 (139.6, 142.6) | 0.373 |
| Diastolic BP, mmHg | 78.0 (77.6, 78.4) | 78.5 (78.0, 78.9) | 78.4 (77.6, 79.2) | 0.258 |
| Hypertension, n (%) | 1373 (51%) | 1411 (53%) | 373 (50%) | 0.302 |
| Adults 18 to 70 years | n = 1124 | n = 1138 | n = 313 | |
| Age, years | 56.3 (55.4, 57.1) | 56.4 (55.6, 57.3) | 55.8 (54.2, 57.5) | 0.835 |
| Systolic BP, mmHg | 135.0 (133.9, 136.0)a | 136.1 (135.0, 137.2)ab | 137.6 (135.5, 139.6)b | 0.026 |
| Diastolic BP, mmHg | 79.4 (78.9, 80.0)a | 80.0 (79.4, 80.5)ab | 81.4 (80.3, 82.5)b | 0.013 |
| Hypertension, n (%) | 464 (40) | 514 (44) | 149 (46) | 0.072 |
CC (wild type), CT (heterozygous), TT (homozygous variant), genotypes for the MTHFR 677C→T polymorphism
Data are expressed as mean (95% CI) for age, as adjusted mean (95% CI) for blood pressure, and n (%) for hypertension
BP blood pressure
aHypertension defined as systolic BP of ≥ 140 and/or a diastolic BP of ≥ 90 mmHg [1]
bDifferences in blood pressure between genotype groups were assessed by one-way ANCOVA with adjustment for age, sex, BMI, alcohol, total cholesterol, antihypertensive drugs use and study cohort following log-transformation of data for normalisation purposes, as appropriate. Different superscript letters (i.e. a, b) within a row indicate significant differences by Bonferroni post hoc test, whilst the same letter (i.e. a, a) indicates no significant differences. Categorical variables were assessed using chi-square analysis