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. 2020 Nov 11;21:57. doi: 10.1186/s12865-020-00386-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Correlation of candidate miRNAs with EV numbers and oxidative stress associated metabolites. a. Metabolites associated with oxidative stress and immune activation are increased in HIV-positive versus HIV-negative subjects. Medians are represented by horizontal bars, boxes span the IQR, and whiskers extend to extreme data points within 1.5 times IQR. Outliers are plotted outside 1.5 times the IQR. P-values were calculated by Mann-Whitney test (n = 8 HIV-negative, n = 8 HIV-positive subjects). Scatter plots show correlation of miR-21-5p, miR-27b-3p, miR-146a-5p, and miR-423-5p with EV numbers (b) and oxidative stress associated metabolites cystine, cysteine, cysteine-s-sulfate, and cys-gly, oxidized (c) in HIV-positive (n = 8) and HIV-negative (n = 8) subjects. Correlation coefficients and p-values are shown above each plot. K:T ratio, kynurenine:tryptophan ratio; RQ, relative quantity