Table 2.
Differential expression analysis of top 50 miRNAs in HIV-positive (n = 12) versus HIV-negative (n = 8) subjects from the test cohort
| baseMean | Log2 FC | P value | P adj | |
|---|---|---|---|---|
| hsa-miR-26a-5p | 620 | −0.106 | 0.8216 | 0.9831 |
| hsa-miR-148a-3p | 514.38 | 0.798 | 0.2256 | 0.6636 |
| hsa-miR-21-5p* | 493.5 | −0.405 | 0.4709 | 0.981 |
| hsa-let-7i-5p | 318.91 | −0.191 | 0.7614 | 0.9831 |
| hsa-miR-122-5p* | 288.3 | 0.953 | 0.4941 | 0.9831 |
| hsa-miR-1-3p | 243.23 | 0.662 | 0.6196 | 0.9831 |
| hsa-let-7a-5p* | 224.95 | 1.512 | 0.0699 | 0.3493 |
| hsa-let-7f-5p | 216.84 | −1.594 | 0.1263 | 0.4859 |
| hsa-miR-423-5p* | 210.36 | 0.239 | 0.8054 | 0.9831 |
| hsa-let-7b-5p | 181.67 | 1.098 | 0.2963 | 0.7134 |
| hsa-miR-126-3p | 134.04 | 3.067 | 0.0056 | 0.1169 |
| hsa-let-7 g-5p | 113.18 | −0.108 | 0.9161 | 0.9831 |
| hsa-let-7c-5p | 109.04 | 2.39 | 0.0466 | 0.259 |
| hsa-miR-30d-5p | 102.88 | −1.677 | 0.2039 | 0.6371 |
| hsa-miR-99a-5p | 96.3 | 0.527 | 0.6449 | 0.9831 |
| hsa-miR-92a-3p | 86.99 | 0.779 | 0.4643 | 0.981 |
| hsa-miR-10a-5p* | 83 | 2.9 | 0.0213 | 0.1779 |
| hsa-miR-100-5p | 80.05 | 1.389 | 0.2811 | 0.7134 |
| hsa-miR-22-3p | 79.59 | 2.307 | 0.0898 | 0.3743 |
| hsa-miR-143-3p | 73.61 | 1.308 | 0.3139 | 0.7134 |
| hsa-miR-486-5p | 69.46 | 1.373 | 0.3024 | 0.7134 |
| hsa-miR-1246 | 64.35 | −2.662 | 0.0342 | 0.2441 |
| hsa-miR-155-5p | 64.01 | −0.322 | 0.7998 | 0.9831 |
| hsa-miR-151a-3p | 59.85 | −0.261 | 0.8725 | 0.9831 |
| hsa-miR-7-5p | 57.03 | 0.038 | 0.9751 | 0.9917 |
| hsa-miR-99b-5p | 51.54 | −0.933 | 0.7672 | 0.9831 |
| hsa-miR-27a-3p | 50.45 | 1.684 | 0.1728 | 0.5761 |
| hsa-miR-320a | 50.4 | 0.352 | 0.811 | 0.9831 |
| hsa-miR-30c-5p | 49.92 | −1.558 | 0.2631 | 0.7134 |
| hsa-let-7d-5p | 44.98 | 2.287 | 0.0391 | 0.2447 |
| hsa-miR-101-3p | 44.39 | −0.6 | 0.674 | 0.9831 |
| hsa-miR-192-5p | 41.22 | 2.429 | 0.0795 | 0.3615 |
| hsa-miR-222-3p | 41.18 | 0.194 | 0.8841 | 0.9831 |
| hsa-miR-199a-3p | 40.5 | 0.08 | 0.9438 | 0.9831 |
| hsa-miR-199b-3p | 40.5 | 0.08 | 0.9438 | 0.9831 |
| hsa-miR-10b-5p | 34.17 | 0.197 | 0.8896 | 0.9831 |
| hsa-miR-181a-5p | 33.66 | −5.884 | 1.59E-05 | 0.0008 |
| hsa-miR-27b-3p* | 31.04 | 2.583 | 0.0112 | 0.1169 |
| hsa-miR-26b-5p | 30.29 | 0.012 | 0.9917 | 0.9917 |
| hsa-miR-378a-3p | 29.32 | 3.691 | 0.0117 | 0.1169 |
| hsa-miR-24-3p | 28.94 | 1.696 | 0.1589 | 0.5674 |
| hsa-miR-191-5p | 28.19 | −0.71 | 0.676 | 0.9831 |
| hsa-miR-25-3p | 25.4 | 0.235 | 0.8851 | 0.9831 |
| hsa-miR-125a-5p | 22.86 | −4.3 | 0.0104 | 0.1169 |
| hsa-miR-451a | 22.8 | 0.443 | 0.7961 | 0.9831 |
| hsa-miR-146a-5p* | 22.33 | 0.856 | 0.5596 | 0.9831 |
| hsa-miR-125b-5p* | 14.62 | −0.665 | 0.6723 | 0.9831 |
| hsa-miR-218-5p | 14.38 | 1.004 | 0.5147 | 0.9831 |
| hsa-miR-423-3p | 12.6 | 0.485 | 0.7753 | 0.9831 |
| hsa-miR-30a-5p | 10.24 | −0.284 | 0.8542 | 0.9831 |
* miRNAs selected for qRT-PCR validation are indicated with an asterisk. Significant raw p-values are in bold