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. 2020 Nov 11;11:479. doi: 10.1186/s13287-020-01990-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Downregulation of FOXF2 inhibits collagen aggregation, cell proliferation and β-catenin expression in TGF-β1-treated HESCs ex vivo. a Relative FOXF2 mRNA expression after si-FOXF2 transfection of primary HESCs. Measurement data are presented as the means ± SEM, n = 3; ***P < 0.001, one-way ANOVA. b Relative expression of mRNAs in primary HESCs transfected with si-FOXF2 before and after TGF-β1 treatment. Data are expressed as the means ± SEM, n = 3; *P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA. c Protein expression in primary HESCs transfected with si-FOXF2 before and after TGF-β1 treatment. d The protein relationship between TGF-β1 and β-catenin was forecasted using STRING tools. e EdU assay showing changes in the proliferation of primary HESCs transfected with si-FOXF2 before and after TGF-β1 treatment. f CCK8 assay showing the proliferation rate of primary HESCs transfected with si-FOXF2 before and after TGF-β1 treatment. Measurement data are expressed as the means ± SEM, n = 3; *P < 0.05, **P < 0.01, one-way ANOVA. g IF showing the protein expression levels of α-SMA and COLIA1 in primary HESCs transfected with si-FOXF2 before and after TGF-β1 treatment. h Flow cytometry analysis showing changes in the cell cycle of primary HESCs transfected with si-FOXF2 before and after TGF-β1 treatment