Table 1.

Key points of differentiation between RTH-α and RTH-β

TR types	RTH type	Mutation receptor	Clincal manifestations	Treatment
TR-α1: Heart, muscle tissue TR-α2: Widely distributed TR-β1: Brain, liver, kidney TR-β2: Hypothalamus, pituitary gland	RTH-α	TR-α	Anemia, Constipation, Growth retardation, Developmental delay, Motor and Cognitive development delay	L-T4
	RTH-β	TR-β	General, Pituitary and Peripheral RTH-β Vary from hyperthyroidism to hypothyroidism or simple goiter	L-T4 or L-T3, TRIAC, DT4, beta-blockers