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. 2020 Nov 10;12:145. doi: 10.1186/s13195-020-00716-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Expression of hub genes detected in the PPI network analysis. a The expression of all hub genes in blood cells (red) and brain tissues (yellow) were checked in the Human Protein Atlas database. An X-axis represents the resulting transcript expression values, denoted normalized expression (NX), which were calculated for each gene in every sample. b, c Gene expression was further examined using our 610 blood samples (271 from patients with AD, 248 from patients with MCI, and 91 from CNs). The difference in gene expression was examined between diseases (b) and between MCI-C and MCI-NC patients (n = 123; 48 MCI-C and 75 MCI-NC) (c). b, c P values are displayed above the boxplots. *Statistically significant differences, “exactTest” function in edgeR; TMM, trimmed mean of M values