Table 2.
Pre-existing comorbidities in non-transplant and transplant patients with NDMM stratified by age
| Overall | < 65 years | 65–74 years | 75–84 years | 85+ years | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Non-transplant (N = 22,062) | Transplant (N = 2763) | Non-transplant (n = 5197) | Transplant (n = 1378) | Non-transplant (n = 7741) | Transplant (n = 1298) | Non-transplant (n = 7536) | Transplant (n = 87) | Non-transplant (n = 1588) | Transplant (n = 0) | |
| Charlson Comorbidity Index during 180 days prior to index MM diagnosis | ||||||||||
| Mean (SD) | 1.5 (1.8) | 1.2 (1.5) | 0.9 (1.6) | 0.7 (1.3) | 1.5 (1.8) | 1.6 (1.6) | 1.6 (1.8) | 1.5 (1.3) | 2.1 (1.9) | – |
| Median (Q1–Q3) | 1.0 (0–2.0) | 1.0 (0–2.0) | 0 (0–1.0) | 0 (0–1.0) | 1.0 (0–2.0) | 2.0 (0–2.0) | 1.0 (0–2.0) | 2.0 (0–2.0) | 2.0 (0–3.0) | – |
| Min, max | 0, 13 | 0, 11 | 0, 13 | 0, 9 | 0, 12 | 0, 11 | 0, 12 | 0, 5 | 0, 10 | – |
| Comorbidities during 180 days prior to index MM diagnosis, n (%) | ||||||||||
| Any comorbidity below | 14,539 (65.9) | 1638 (59.3) | 2556 (49.2) | 746 (54.1) | 5186 (67.0) | 826 (63.6) | 5476 (72.7) | 66 (75.9) | 1321 (83.2) | – |
| Cardiac arrhythmia | 4327 (19.6) | 294 (10.6) | 529 (10.2) | 139 (10.1) | 1396 (18.0) | 143 (11.0) | 1854 (24.6) | 12 (13.8) | 548 (34.5) | – |
| Congestive heart failure | 2984 (13.5) | 117 (4.2) | 493 (9.5) | NR | 956 (12.3) | 59 (4.5) | 1179 (15.6) | NR | 356 (22.4) | – |
| Hypertension, complicated | 3718 (16.9) | 260 (9.4) | 603 (11.6) | NR | 1274 (16.5) | 143 (11.0) | 1435 (19.0) | NR | 406 (25.6) | – |
| Hypertension, simple | 11,698 (53.0) | 1316 (47.6) | 1871 (36.0) | 569 (41.3) | 4215 (54.5) | 692 (53.3) | 4490 (59.6) | 55 (63.2) | 1122 (70.7) | – |
| Hepatic disease | 972 (4.4) | 151 (5.5) | 269 (5.2) | NR | 392 (5.1) | 71 (5.5) | 241 (3.2) | NR | 70 (4.4) | – |
| Pulmonary circulation disorders | 1027 (4.7) | 56 (2.0) | 172 (3.3) | NR | 357 (4.6) | 23 (1.8) | 388 (5.1) | NR | 110 (6.9) | – |
| Renal impairment | 5317 (24.1) | 471 (17.0) | 932 (17.9) | 230 (16.7) | 1829 (23.6) | 222 (17.1) | 2028 (26.9) | 19 (21.8) | 528 (33.2) | – |
| Valvular disease | 2258 (10.2) | 158 (5.7) | 282 (5.4) | NR | 744 (9.6) | 90 (6.9) | 966 (12.8) | NR | 266 (16.8) | – |
MM Multiple myeloma, NDMM Newly diagnosed multiple myeloma, NR Not reported, Q Quartile, SD Standard deviation
Values of 1–10 have not been reported in any cell in this table to conform to the Centers for Medicare and Medicaid Services cell size suppression policy; Similarly, values have not been reported for categorical variables and by subgroup to avoid making it possible to calculate the values of the NR cells