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. 2020 Sep 24;41(11):1416–1426. doi: 10.1038/s41401-020-00517-z

Fig. 4. iNKT cells activated by OCH attenuate progressive ISO stimulation-induced cardiac fibrosis in mice.

Fig. 4

WT C57BL/6 mice received ISO (5 mg/kg per day) alone for 7 days or with OCH (3 μg/mouse) every other day. a HE staining and Masson’s trichrome staining were performed, and the fibrotic area/LV percentage (b) and ratio of heart weight to body weight (c) were calculated. d, e, f Whole-heart lysates were subjected to immunoblotting with the indicated antibody. GAPDH was used as the loading control. The data are expressed as a ratio of the experimental value to the mean value of the saline group. g, h, i Echocardiography was performed to evaluate cardiac function. The data are expressed as the mean ± SD. *P < 0.05 and **P < 0.01.