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. 2020 Jul 21;598(18):3911–3925. doi: 10.1113/JP279947

Figure 1. TRPC1 compose PKC‐dependent SOCs in native contractile VSMCs.

Figure 1

A, representative trace and mean I–V relationships showing that the development of store‐operated whole‐cell currents from control to peak levels in freshly isolated rat mesenteric artery VSMCs following obtaining whole‐cell configuration (wc) was inhibited by bath application of Pico145. Vertical deflections represent currents evoked by voltage ramps from +100 mV to −150 mV (750 ms duration) every 30 s from a holding potential of 0 mV. B and C, Mean data showing that bath applications of T1E3 (1 μg mL−1) and GF109203X (3 μm) inhibited store‐operated whole‐cell currents.