Table 2.

Treatment-related adverse events

	All grade	Grade 3–4
Patients with ≥1 events	36 (97%)	26 (70%)
Fatigue	27 (73%)	6 (16%)
Fever	27 (73%)	2 (5%)
Thrombocytopenia	25 (68%)	4 (11%)
RCCEP	23 (62%)	0
Nausea	23 (62%)	5 (14%)
Hypocalcemia	23 (62%)	0
Amenia	22 (59%)	2 (5%)
Vomiting	20 (54%)	4 (11%)
Leukocytopenia	19 (51%)	4 (11%)
Hyponatremia	19 (51%)	1 (3%)
Neutropenia	18 (49%)	5 (14%)
AST increased	18 (49%)	1 (3%)
Hypoalbuminemia	16 (43%)	0
Constipation	14 (38%)	2 (5%)
ALT increased	14 (38%)	0
Neurotoxicity	12 (32%)	0
Hypokalemia	11 (30%)	7 (19%)
Alopecia	11 (30%)	0
Skin pigmentation	10 (27%)	0
Diarrhea	8 (22%)	1 (3%)
ALP increased	8 (22%)	0
GGT increased	8 (22%)	5 (14%)
Anorexia	7 (19%)	0
Peripheral neurotoxicity	6 (16%)	1 (3%)
Biliary tract infection	5 (14%)	5 (14%)
Blood bilirubin increased	5 (14%)	1 (3%)
Hypomagnesemia	5 (14%)	0
Insomnia	5 (14%)	0
Parodontopathy	5 (14%)	0
Hand-foot syndrome	4 (11%)	0
Hypophosphatemia	4 (11%)	2 (5%)
Mucositis	3 (8%)	1 (3%)
Rash	3 (8%)	2 (5%)

Data are n (%) in all treated patients (n=37). The table lists treatment-related adverse events reported in ≥10% patients or grade 3–4 treatment-related adverse events. Patients are counted for each applicable specific adverse event and could have more than one treatment-related event.

ALP, alkaline phosphatase; ALT, alanine aminotransferase; GGT, gamma-glutamyl transferase; RCCEP, reactive cutaneous capillary endothelial proliferation.