Table 7.

The individual bias variables that best explained the diagnoses based on adjusted R-squared: major depressive episodes, dysthymic disorder and manic episodes by assumed input symptom prevalence and correlations

Assumed correlations between input symptoms	Assumed prevalence of input symptoms	Major depressive episodes	Dysthymic disorder	Manic episodes
0	0.05	mde_bias2	dys_bias	man_bias2
0	0.05	0 (95% CI 0 to 0)	0.028 (95% CI 0.028 to 0.028)	0.001 (95% CI 0.001 to 0.001)
0	0.1	mde_bias2	dys_bias	man_bias2
0	0.1	0.004 (95% CI 0.004 to 0.004)	0.053 (95% CI 0.053 to 0.054)	0.011 (95% CI 0.011 to 0.011)
0	0.3	mde_bias2	dys_bias	man_bias1
0	0.3	0.015 (95% CI 0.015 to 0.015)	0.045 (95% CI 0.045 to 0.045)	0.089 (95% CI 0.089 to 0.09)
0	0.5	mde_bias	dys_bias	man_bias1
0	0.5	0.013 (95% CI 0.013 to 0.014)	0.007 (95% CI 0.007 to 0.007)	0.035 (95% CI 0.034 to 0.035)
0	0.7	mde_bias	dys_bias	man_bias1
0	0.7	0.01 (95% CI 0.01 to 0.01)	0 (95% CI 0 to 0)	0.002 (95% CI 0.002 to 0.002)
0.1	0.05	mde_bias2	dys_bias	man_bias1
0.1	0.05	0.037 (95% CI 0.037 to 0.037)	0.113 (95% CI 0.113 to 0.114)	0.083 (95% CI 0.083 to 0.084)
0.1	0.1	mde_bias2	dys_bias	man_bias1
0.1	0.1	0.047 (95% CI 0.047 to 0.048)	0.122 (95% CI 0.121 to 0.122)	0.116 (95% CI 0.115 to 0.116)
0.1	0.3	mde_bias2	dys_mi_bias	man_bias1
0.1	0.3	0.077 (95% CI 0.077 to 0.077)	0.105 (95% CI 0.105 to 0.106)	0.198 (95% CI 0.197 to 0.198)
0.1	0.5	mde_bias2	dys_mi_bias	man_bias1
0.1	0.5	0.079 (95% CI 0.079 to 0.08)	0.073 (95% CI 0.073 to 0.073)	0.166 (95% CI 0.166 to 0.167)
0.1	0.7	mde_bias2	dys_mi_bias	man_bias1
0.1	0.7	0.065 (95% CI 0.065 to 0.065)	0.047 (95% CI 0.046 to 0.047)	0.094 (95% CI 0.093 to 0.094)
0.4	0.05	mde_bias1	dys_mi_bias	man_bias1
0.4	0.05	0.294 (95% CI 0.293 to 0.295)	0.415 (95% CI 0.413 to 0.416)	0.432 (95% CI 0.431 to 0.433)
0.4	0.1	mde_bias1	dys_mi_bias	man_bias1
0.4	0.1	0.304 (95% CI 0.303 to 0.304)	0.419 (95% CI 0.418 to 0.42)	0.445 (95% CI 0.444 to 0.445)
0.4	0.3	mde_bias1	dys_mi_bias	man_bias1
0.4	0.3	0.335 (95% CI 0.334 to 0.335)	0.411 (95% CI 0.411 to 0.412)	0.473 (95% CI 0.472 to 0.473)
0.4	0.5	mde_bias1	dys_mi_bias	man_bias1
0.4	0.5	0.354 (95% CI 0.354 to 0.355)	0.395 (95% CI 0.395 to 0.396)	0.475 (95% CI 0.474 to 0.475)
0.4	0.7	mde_bias1	dys_mi_bias	man_bias1
0.4	0.7	0.356 (95% CI 0.355 to 0.356)	0.367 (95% CI 0.366 to 0.367)	0.451 (95% CI 0.45 to 0.451)
0.7	0.05	mde_bias1	dys_mi_bias	man_bias1
0.7	0.05	0.616 (95% CI 0.615 to 0.617)	0.705 (95% CI 0.704 to 0.706)	0.723 (95% CI 0.722 to 0.724)
0.7	0.1	mde_bias1	dys_mi_bias	man_bias1
0.7	0.1	0.611 (95% CI 0.611 to 0.612)	0.699 (95% CI 0.698 to 0.699)	0.72 (95% CI 0.72 to 0.721)
0.7	0.3	mde_bias1	dys_mi_bias	man_bias1
0.7	0.3	0.623 (95% CI 0.623 to 0.624)	0.699 (95% CI 0.699 to 0.7)	0.728 (95% CI 0.728 to 0.729)
0.7	0.5	mde_bias1	dys_mi_bias	man_bias1
0.7	0.5	0.632 (95% CI 0.632 to 0.633)	0.696 (95% CI 0.696 to 0.697)	0.731 (95% CI 0.731 to 0.732)
0.7	0.7	mde_bias1	dys_mi_bias	man_bias1
0.7	0.7	0.639 (95% CI 0.638 to 0.639)	0.693 (95% CI 0.692 to 0.693)	0.732 (95% CI 0.731 to 0.732)
0.9	0.05	mde_bias1	dys_mi_bias	man_bias1
0.9	0.05	0.777 (95% CI 0.776 to 0.778)	0.835 (95% CI 0.834 to 0.835)	0.847 (95% CI 0.847 to 0.848)
0.9	0.1	mde_bias1	dys_mi_bias	man_bias1
0.9	0.1	0.788 (95% CI 0.788 to 0.789)	0.842 (95% CI 0.841 to 0.843)	0.855 (95% CI 0.854 to 0.855)
0.9	0.3	mde_bias1	dys_mi_bias	man_bias1
0.9	0.3	0.807 (95% CI 0.806 to 0.807)	0.854 (95% CI 0.853 to 0.854)	0.867 (95% CI 0.867 to 0.868)
0.9	0.5	mde_bias1	dys_mi_bias	man_bias1
0.9	0.5	0.811 (95% CI 0.811 to 0.811)	0.855 (95% CI 0.855 to 0.856)	0.87 (95% CI 0.87 to 0.871)
0.9	0.7	mde_bias1	dys_mi_bias	man_bias1
0.9	0.7	0.812 (95% CI 0.811 to 0.812)	0.853 (95% CI 0.853 to 0.853)	0.869 (95% CI 0.869 to 0.87)

See table 2 to 4 for variable definitions. Adjusted R-squared is derived from linear regressions using individual bias variables as predictor with 95% confidence intervals (CIs) derived from 100 simulations for each combination of assumed input symptom prevalence and correlations.

CI, confidence interval.