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. 2020 Oct 28;11:586980. doi: 10.3389/fendo.2020.586980

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Copyright © 2020 Zurkinden, Sviridov, Vogt and Escher

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Possible atherosclerotic mechanisms. Hepatic CYP7A1 and CYP3A11 were downregulated to the same level with both diets but only WD-CA was atherogenic. (A) In WD-CA fed mice, atherosclerosis was mainly driven by high circulating TC concentrations, low HDL-C and high LDL-C, and reduced cholesterol output in feces. The increased plasma LDL-C was attributed to the reduced LDLR leading to a diminished LDL-C uptake by the liver, driven by a decreased SREPB2. In the intestine, WD-CA promoted the release of FGF15 as well as increased expression of ABCA1, ABCG5, ABCG8, and SR-B1. (B) WD-CDCA fed mice failed to develop atherosclerosis, because of low plasma cholesterol, high HDL-C and low LDL-C, the tremendous increase of BAs excretion in feces. In the intestine, WD-CDCA also strongly down regulated CYP3A11, whereas FGF-15 was slightly increased and ABCA1 and ABCG5/G8 were unchanged.