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. 2020 Oct 28;11:592865. doi: 10.3389/fimmu.2020.592865

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Copyright © 2020 Ryffel, Huang, Robinet, Panek, Couillin, Erard, Piotet, Le Bert, Mackowiak, Torres Arias, Dimier-Poisson and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-22 confers protection in IL-33R/ST2 deficient mice upon T. gondii infection Infection by T. gondii infection induces enhanced IL22 mRNA and protein expression in ST2 deficient mice (A,B) and increased IL-33 expression (B). Administration of rmIL-22 reduces MPO activity, CXCL1/KC levels, neutrophil recruitment (C) and severity of ileitis in B6 mice (D). By contrast, IL-22 antibody blockade in IL-33R/ST2 deficient mice increased MPO activity, CXCL1/KC levels and neutrophil recruitment (E) and enhanced severity of ileitis (F). Analysis at day 7 post-infection. Values are representative of two independent experiments.