Table 3.
Baseline demographic and oncological predictors (univariate and multivariate models).
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Factor | p-value | p-value | HR(95% CI) | Estimated median OS (years) |
| Sex | 0.15 | |||
| Age | 0.3 | |||
| Symptoms | 0.6 | |||
| KPS score | 0.01 | 0.03 | ||
| <90 | 1 | 8.75 | ||
| ≥90 | 0.48 (0.25-0.91) | 16.25 | ||
| Main tumor location | 0.003 | NS | ||
| Number of lobes involved | <0.0001 | NS | ||
| Tumor side | 0.56 | |||
| Contrast enhancement | 0.5 | |||
| Initial tumor volume | 0.01 | 0.05 | ||
| <49 cm3 | 1 | 16.9 | ||
| ≥49 cm3 | 1.72 (1.14-2.59) | 10.8 | ||
| Histological type | 0.5 | |||
| Type of first-line treatment | 0.2 | |||
| Type of first-line surgery | 0.18 | |||
| Postoperative volume | 0.015 | 0.015 | ||
| ≥10 cm3 | 1 | 11.7 | ||
| <10 cm3 | 0.65 (0.36-1.18) | 17.9 | ||
| no residual tumor | 0.24 (0.08-0.66) | Not reached | ||
| Type of first CT | 0.077 | NS | ||
| Moment of RT | <0.0001 | <0.0001 | ||
| after anaplastic transformation | 1 | 9 | ||
| early | 0.27 (0.14-0.50) | 15.3 | ||
| delayed | 0.36 (0.23-0.56) | 13.7 |
HR, hazard ratio; CI, confidence interval; OS, overall survival; RT, radiotherapy; CT, chemotherapy; NS, not significant.