Fig. 3.

Molecular docking model. (A) The binding pattern between ACE2 and SARS-CoV (PDB: 6ACG). Red circle: the candidate protein binding pocket in ACE2; Black box: the protein binding interface between ACE2 and SARS-CoV. (B) Hydrophilic-hydrophobic interaction between (i) puerarin and ACE2 in protein binding pocket, and (ii) puerarin and relative amino acids residues. (C) Hydrophilic-hydrophobic interaction between (i) quercetin and ACE2 in protein binding pocket, and (ii) quercetin and relative amino acids residues. (D) Hydrophilic-hydrophobic interaction between (i) kaempferol and ACE2 in protein binding pocket, and (ii) kaempferol and relative amino acids residues. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)