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. 2020 Nov 11;18:3518–3527. doi: 10.1016/j.csbj.2020.11.010

Table 3.

The enrichment analysis of candidate targets of quercetin.

Type Term Gene count P-value
GO GO-BP:positive regulation of transcription from RNA polymerase II promoter 38 1.26E-16
GO-BP:positive regulation of transcription, DNA-templated 27 1.31E-14
GO-BP:response to drug 25 6.40E-18
GO-BP:inflammatory response 22 1.04E-12
GO-BP:signal transduction 22 1.79E-04
GO-BP:positive regulation of gene expression 20 1.17E-13
GO-BP:negative regulation of cell proliferation 19 1.23E-09
GO-BP:apoptotic process 18 1.44E-06
GO-BP:negative regulation of transcription from RNA polymerase II promoter 18 3.32E-05
GO-BP:oxidation–reduction process 17 1.12E-05
GO-MF:protein binding 102 1.06E-10
GO-MF:identical protein binding 29 1.31E-12
GO-MF:enzyme binding 25 3.80E-17
GO-MF:transcription factor activity, sequence-specific DNA binding 23 2.66E-06
GO-MF:DNA binding 23 0.0066762
GO-MF:protein homodimerization activity 22 1.16E-07
GO-MF:transcription factor binding 19 4.28E-12
GO-MF:ATP binding 19 0.0310054
GO-MF:sequence-specific DNA binding 18 3.44E-07
GO-MF:protein heterodimerization activity 16 2.20E-06
KEGG KEGG:Pathways in cancer 42 3.31E-23
KEGG:Hepatitis B 27 1.44E-20
KEGG:PI3K-Akt signaling pathway 25 1.06E-09
KEGG:HTLV-I infection 23 8.94E-11
KEGG:Proteoglycans in cancer 22 6.43E-12
KEGG:MAPK signaling pathway 21 3.60E-09
KEGG:MicroRNAs in cancer 21 2.95E-08
KEGG:HIF-1 signaling pathway 20 4.96E-16
KEGG:TNF signaling pathway 20 4.34E-15
KEGG:Influenza A 20 3.66E-11