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Model for how age-related changes in hematopoietic stem cell (HSC) epigenetic and metabolic state and signals from the dysregulated aging bone marrow (BM) microenvironment lead to clonal expansion and predisposition to leukemic transformation. Gray, functional HSCs; yellow/orange, HSCs that acquired mutations in epigenetic and metabolic genes; red, leukemic stem cells (LSCs). Partially based on [159].
