Table 7.
Cytotoxicity tests with a set of PepBiotics.
| Peptide | Average (%) | SD | P-value |
|---|---|---|---|
| No Peptide | 100.0 | ||
| EtOH | 17.5 | 2.9 | .00045 |
| CR-170 | 94.7 | 16.9 | .58 |
| CR-171 | 91.0 | 21.6 | .46 |
| CR-172 | 66.7 | 24.8 | .074 |
| CR-182 | 104.3 | 24.0 | .79 |
| CR-184 | 95.8 | 13.6 | .58 |
| CATH-2 | 45.8 | 9.3 | .010 |
To determine cytotoxic effects of PepBiotics cells were exposed to 5 μM of the indicated peptide. Primary human nasal epithelial cells were used that were isolated and cultivated to confluency in Bronchial Epithelical Cell medium as described in Methods. Controls included no peptide (100% viability) and ethanol (total loss of cell viability). Experiments were performed in triplo.