Table 2.

Toxicity profiles (toxicity grades according to CTC‐AE of the National Cancer Institute, version 3.0 [per person]) during treatment

	Preoperative chemoradiation (n = 37;%)				Postoperative chemotherapy (n = 33;%)
	1	2	3	4	1	2	3	4
Hematological toxicity
Leukopenia	6 (16.2)	10 (27.0)	2 (5.4)	0	11 (33.3)	13 (39.4)	3 (9.1)	0
Neutropenia	6 (16.2)	8 (21.6)	0	0	10 (30.3)	10 (30.3)	9 (27.3)	0
Anemia	19 (51.4)	1 (2.7)	0	0	22 (66.7)	5 (15.2)	0	0
Thrombocytopenia	22 (59.5)	0	0	0	20 (50.6)	4 (12.1)	3 (9.1)	0
Febrile neutropenia	–	–	0	0	–	–	1 (3.0)	0
Non‐hematological toxicity
Anorexia	20 (54.1)	0	1 (2.7)	0	18 (54.5)	6 (18.2)	0	0
Nausea	24 (64.9)	0	1 (2.7)	0	16 (48.5)	2 (6.1)	1 (3.0)	0
Vomiting	5 (13.5)	2 (5.4)	0	0	4 (12.1)	1 (3.0)	1 (3.0)	0
Stomatitis	10 (27.0)	0	0	0	10 (30.3)	2 (6.1)	0	0
Constipation	12 (32.4)	1 (2.7)	0	0	1 (3.0)	0	0	0
Diarrhea	13 (35.1)	5 (13.5)	2 (5.4)	0	2 (6.1)	7 (21.2)	0	0
Sensory neuropathy	23 (62.2)	0	0	0	24 (72.7)	3 (9.1)	1 (3.0)	0
Hand–foot syndrome	1 (2.7)	0	0	0	3 (9.1)	1 (3.0)	0	0
AST/ALT elevation	11 (29.0)	0	0	0	8 (24.2)	0	1 (3.0)	0
Hyperbilirubinemia	8 (21.6)	4 (10.8)	0	0	9 (27.3)	4 (12.1)	1 (3.0)	0

ALT, alanine aminotransferase; AST, aspartate aminotransferase; CTC‐AE, Common Terminology Criteria for Adverse Events; –, not applicable.