Table 3.
Univariable Cox proportional hazards models for treatment‐free survival in Chinese patients with chronic lymphocytic leukemia (n = 172)
| Characteristic | No. of cases | Hazard ratio (95% CI) | P‐value |
|---|---|---|---|
| Age (years), <60 vs ≥60 | 172 | 0.141 (0.894–2.197) | 0.1410 |
| Gender (male vs female) | 172 | 1.326 (0.825–2.133) | 0.2440 |
| Binet stage A (vs C) | 136 | 0.231 (0.131–0.405) | <0.0001 |
| Binet stage B (vs C) | 89 | 0.979 (0.589–1.626) | 0.9340 |
| CD38 ≥ 30% (vs <30%) | 169 | 1.493 (0.948–2.354) | 0.0840 |
| ZAP‐70 ≥ 20% (vs <20%) | 167 | 1.959 (1.230–3.120) | 0.0050 |
| IGHV mutation (vs non‐mutation) | 153 | 0.478 (0.303–0.755) | 0.0020 |
| p53 mutation (vs non‐mutation) | 156 | 1.507 (0.879–2.582) | 0.1360 |
| Unfavorable karyotypea (vs favorablea) | 54 | 1.072 (0.457–2.513) | 0.8730 |
| Others (vs favorablea) | 127 | 0.590 (0.261–1.335) | 0.2050 |
| CD20 ≥ 60.3% (vs <60.3%) | 172 | 0.452 (0.232–0.884) | 0.0200 |
a
†Unfavorable karyotype, del(17) and del(11q). ‡Favorable karyotype, del(13q24) as the sole abnormality. CI, confidence interval; IGHV, variable region of immunoglobulin genes; MFI, mean fluorescence intensity; ZAP‐70, zeta‐associated protein‐70. Bold values indicate statistically significant.