Figure 5.

Summary of the relationship between the length of the truncated adenomatous polyposis coli (APC) proteins expressed in mutant mice and their phenotypes. Full‐length APC protein is shown together with the major functional domains at the top. The 10 main Apc mutations reported previously and our novel mutation, Apc1576 (★), are described to the left of the truncated APC proteins that they encode. The top eight mutants developed multiple intestinal tumors,15, 16, 17, 18, 19, 20, 21, 22 whereas the lower three did not. Both Apc1572T23 and Apc1576 similarly developed breast cancer, but only Apc1576 developed osteomas. Of all these mutants, only in Apc1638T are the heterozygous mutants tumor‐free and the homozygote mutants viable.24 a.a., amino acids.