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. 2013 May 15;104(8):1062–1066. doi: 10.1111/cas.12182

Figure 2.

Figure 2

(a) Effects of 4β‐(benzoyl‐thioureido)‐4‐deoxypodophyllotoxin (HY‐1) and camptothecin (CPT) on human topoisomerase I‐mediated decatenation activity of pBR322. RLX, relaxed pBR322; SC, supercoiled pBR322. (b) Effects of HY‐1 and etoposide (VP‐16) on human topoisomerase II‐mediated decatenation activity of kinetoplast DNA (kDNA). Minicircles indicate no drug. DNA samples were separated by electrophoresis on agarose gels containing ethidium bromide (1 mg/mL). Gels were photographed under UV light.