Table 4.
Correlation between mucin expression profiles and CD10, transforming growth factor‐β1 (TGF‐β1), and tumor budding grade at invasion fronts in colorectal cancer
| Factor | n | tCD10 | sCD10 | iCD10 | TGF‐β1 expression | Budding grade | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1+ | 2+ | 3+ | 0 | 1+ | 2+ | 3+ | 0 | 1+ | 2+ | 3+ | 0 | 1+ | 2+ | 3+ | Mean (95% CI) | ||
| MUC1 | ||||||||||||||||||
| 0 | 34 | 18 | 5 | 3 | 8 | 13 | 14 | 2 | 5 | 18 | 15 | 1 | 0 | 11 | 13 | 5 | 5 | 15. 9 (11.5–20.5) |
| 1+ | 43 | 24 | 6 | 3 | 10 | 14 | 12 | 10 | 7 | 22 | 11 | 4 | 6 | 8 | 13 | 17 | 5 | 19.3 (15.9–22.6) |
| 2+ | 68 | 27 | 10 | 11 | 20 | 17 | 31 | 16 | 4 | 28 | 21 | 10 | 9 | 13 | 17 | 24 | 14 | 19.3 (16.8–21.8) |
| 3+ | 61 | 35 | 9 | 9 | 8 | 16 | 15 | 15 | 15 | 20 | 14 | 13 | 14 | 7 | 10 | 21 | 23 | 25. 6 (21.2–29.9) |
| P = 0.684 | P = 0.040 | P < 0.001 | P < 0.001 | P = 0.003 | ||||||||||||||
| MUC2 | ||||||||||||||||||
| 0 | 92 | 39 | 12 | 13 | 28 | 27 | 32 | 16 | 17 | 36 | 30 | 11 | 15 | 12 | 24 | 31 | 25 | 22.0 (19.4–24.7) |
| 1+ | 47 | 20 | 10 | 6 | 11 | 13 | 17 | 11 | 6 | 23 | 12 | 8 | 4 | 12 | 8 | 17 | 10 | 20.0 (16.4–23.5) |
| 2+ | 39 | 23 | 6 | 3 | 7 | 12 | 12 | 11 | 4 | 14 | 12 | 8 | 5 | 7 | 10 | 14 | 8 | 20.7 (15.1–26.2) |
| 3+ | 28 | 22 | 2 | 4 | 0 | 8 | 11 | 5 | 4 | 15 | 7 | 1 | 5 | 8 | 11 | 5 | 4 | 16.8 (12.4–21.3) |
| P < 0.001 | P = 0.678 | P = 0.588 | P = 0.239 | P = 0.337 | ||||||||||||||
| MUC4 | ||||||||||||||||||
| 0 | 100 | 45 | 13 | 15 | 27 | 32 | 37 | 20 | 11 | 46 | 27 | 13 | 14 | 16 | 28 | 36 | 20 | 21.6 (18.9–24.3) |
| 1+ | 38 | 13 | 7 | 2 | 16 | 12 | 12 | 9 | 5 | 18 | 13 | 4 | 3 | 8 | 10 | 8 | 12 | 20.1 (15.3–25.0) |
| 2+ | 38 | 22 | 8 | 5 | 3 | 9 | 13 | 8 | 8 | 13 | 10 | 7 | 8 | 7 | 10 | 11 | 10 | 17.9 (13.6–22.3) |
| 3+ | 30 | 24 | 2 | 4 | 0 | 7 | 10 | 6 | 7 | 11 | 11 | 4 | 4 | 8 | 5 | 12 | 5 | 21.3 (16.9–25.6) |
| P < 0.001 | P = 0.057 | P = 0.320 | P = 0.683 | P = 0.537 | ||||||||||||||
| MUC5 | ||||||||||||||||||
| 0 | 136 | 60 | 25 | 16 | 35 | 43 | 50 | 26 | 17 | 58 | 35 | 20 | 23 | 22 | 35 | 46 | 33 | 20.7 (18.8–22.6) |
| 1+ | 39 | 24 | 1 | 5 | 9 | 8 | 14 | 10 | 7 | 17 | 11 | 5 | 6 | 8 | 10 | 13 | 8 | 20.6 (14.7–26.5) |
| 2+ | 17 | 10 | 2 | 4 | 1 | 2 | 7 | 4 | 4 | 5 | 9 | 3 | 0 | 3 | 5 | 6 | 3 | 24.3 (14.6–34.1) |
| 3+ | 14 | 10 | 2 | 1 | 1 | 7 | 1 | 3 | 3 | 8 | 6 | 0 | 0 | 6 | 3 | 2 | 3 | 14.9 (9.2–20.6) |
| P = 0.019 | P = 0.207 | P = 0.052 | P = 0.087 | P = 0.284 | ||||||||||||||
Values in bold indicate P < 0.05. CI, confidence interval; iCD10, CD10 expression in infiltrating myeloid cells; sCD10, CD10 expression in stromal fibroblast cells; tCD10, CD10 expression in tumor cells.