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. 2013 Mar 28;104(5):584–589. doi: 10.1111/cas.12125

Figure 2.

Figure 2

Sensitivity of various mutations in exon 19 and common EGFR mutations to gefitinib. The various YFP‐EGFR‐ICD exon 19 mutant‐transfected cells showed YFP signal relocation at lower concentrations of gefitinib than WT YFP‐EGFR‐ICD. Sensitivity to gefitinib was different among these mutations. The L861Q and G719X YFP‐EGFR‐ICD‐transfected cells showed YFP signal relocation at 200–500‐nM gefitinib. A, alanine; Del, deletion mutation; EGFR, epidermal growth factor receptor; ins, insertion mutation; P, proline; S, serine; V, valine; VPVAIK, valine‐proline‐valine‐alanine‐isoleucine‐lysine; YFP, yellow fluorescent protein; YFP‐EGFR‐ICD, YFP‐tagged fragments of the EGFR intracellular domain.