Table 3.
Reasons for dose reduction, treatment withdrawal, or treatment schedule change (to 3‐weekly schedule)
| Adverse events | n (69 patients in total [%])a,b |
|---|---|
| Enterocolitis | 37 (53.6) |
| Abdominal pain | 29 (42.0) |
| Diarrhea | 23 (33.3) |
| Weight loss | 18 (26.1) |
| Anorexia | 11 (15.9) |
| Fatigue | 8 (11.6) |
| Neutropenia | 6 (8.7) |
| Stomatitis | 5 (7.2) |
| Infection | 3 (4.3) |
| Emesis | 2 (2.9) |
| Skin rash | 1 (1.4) |
| Hand–foot syndrome | 1 (1.4) |
| Hypoglycemia | 1 (1.4) |
| Cerebral infarct | 1 (1.4) |
a
The percentages and numbers do not balance because of overlap of some reasons (for dose reduction [DR], treatment withdrawal, or treatment schedule change [SC]) during the treatment.
b
Of the 69 patients who underwent DR, SC, or treatment withdrawal because of adverse events, DR (including 10 cases of permanent treatment withdrawal from the first) without SC was applied in 57 patients, SC to the 3‐weekly cycle without DR was applied in three patients, and both DR and SC were applied in nine patients.