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. 2013 May 24;104(7):844–855. doi: 10.1111/cas.12174

Figure 3.

Figure 3

Effects of 5‐HT (10−6 M, 10−9 M) on AKT signaling in hepatocytes after 1 h of treatment. 5‐HT significantly increased pAKT/AKT ratio particularly at 10−6 M as assessed by CASE ELISA (a) and western blot analyses (b). Effects were significantly reversed by the 5‐HT7 inhibitors methiothepin and SB269970 (c,d). Mean ± SEM, n = 4 (three separate experiments), mean ± SEM; *P < 0.05 vs control; §P < 0.05 10−9 M vs 10−6 M 5‐HT; #P < 0.05 vs 10−6 M 5‐HT. Ket, ketanserin; PRX, PRX‐08066; Meth, methiothepin.