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. 2013 Apr 8;104(6):672–680. doi: 10.1111/cas.12143

Figure 7.

Figure 7

Peroxisome proliferator‐activated receptor‐γ (PPARγ) activation inhibited hepatocellular carcinoma (HCC) cell invasion by regulating plasminogen activator inhibitor‐1 (PAI‐1) expression. (a) Western blot evaluated the effect of PPARγ siRNA. (b) Detection of PPARγ overexpression, about 70% of the total cells expressed the fluorescence. (c) Effect of PPARγ knockdown or overexpression on HepG2 cell invasion, PAI‐1 levels (d), and urokinase‐type plasminogen activator (uPA) activity (e) in response to GW1929. Figures showing quantitative analysis include data from at least three independent experiments. Values are expressed as mean ± standard deviation (SD). 1#, PPARγ siRNA1; 2#, PPARγ siRNA2; NC of siRNA group, scramble siRNA; NC of overexpression group, empty pIRES2‐EGFP plasmid; ns, not significant; *P < 0.05; **P < 0.01; ***P < 0.001.