Table 3.
Results of the Connectivity map for HDAC inhibitors, showing list of ‘hit compounds’ as related compounds to the input gene signatures
| Rank | C‐map name | Dose | Cell | Score | Up | Down |
|---|---|---|---|---|---|---|
| (a) Trichostatin A (up, 164; down, 123) | ||||||
| 1 | Trichostatin A | 100 nM | MCF7 | 1.000 | 0.829 | −0.731 |
| 2 | Trichostatin A | 1 μM | MCF7 | 0.990 | 0.818 | −0.727 |
| 3 | Trichostatin A | 100 nM | MCF7 | 0.989 | 0.811 | −0.732 |
| 4 | Trichostatin A | 1 μM | MCF7 | 0.987 | 0.810 | −0.731 |
| 5 | Trichostatin A | 100 nM | MCF7 | 0.983 | 0.814 | −0.720 |
| 6 | Trichostatin A | 100 nM | MCF7 | 0.977 | 0.820 | −0.705 |
| 7 | Trichostatin A | 1 μM | MCF7 | 0.977 | 0.802 | −0.722 |
| 8 | Trichostatin A | 100 nM | MCF7 | 0.974 | 0.826 | −0.695 |
| 9 | Vorinostat | 10 μM | MCF7 | 0.972 | 0.802 | −0.716 |
| 10 | Trichostatin A | 100 nM | MCF7 | 0.970 | 0.807 | −0.707 |
| 11 | Trichostatin A | 100 nM | MCF7 | 0.970 | 0.806 | −0.708 |
| 12 | Trichostatin A | 100 nM | MCF7 | 0.970 | 0.792 | −0.722 |
| 13 | Trichostatin A | 100 nM | MCF7 | 0.969 | 0.821 | −0.691 |
| 14 | Vorinostat | 10 μM | MCF7 | 0.969 | 0.803 | −0.709 |
| 15 | Trichostatin A | 1 μM | MCF7 | 0.968 | 0.799 | −0.711 |
| 16 | Vorinostat | 10 μM | MCF7 | 0.967 | 0.783 | −0.727 |
| 17 | Trichostatin A | 100 nM | MCF7 | 0.967 | 0.770 | −0.738 |
| 18 | Trichostatin A | 1 μM | MCF7 | 0.965 | 0.784 | −0.723 |
| 19 | Trichostatin A | 100 nM | MCF7 | 0.965 | 0.803 | −0.703 |
| 20 | Trichostatin A | 100 nM | MCF7 | 0.963 | 0.787 | −0.716 |
| (b) Vorinostat (up, 157; down, 119) | ||||||
| 1 | Trichostatin A | 1 μM | MCF7 | 1.000 | 0.818 | −0.729 |
| 2 | Trichostatin A | 100 nM | MCF7 | 0.997 | 0.807 | −0.735 |
| 3 | Trichostatin A | 100 nM | MCF7 | 0.992 | 0.817 | −0.716 |
| 4 | Trichostatin A | 1 μM | MCF7 | 0.986 | 0.800 | −0.725 |
| 5 | Trichostatin A | 100 nM | MCF7 | 0.981 | 0.811 | −0.707 |
| 6 | Trichostatin A | 1 μM | MCF7 | 0.980 | 0.799 | −0.716 |
| 7 | Trichostatin A | 100 nM | MCF7 | 0.976 | 0.812 | −0.697 |
| 8 | Trichostatin A | 100 nM | MCF7 | 0.975 | 0.801 | −0.706 |
| 9 | Trichostatin A | 1 μM | MCF7 | 0.970 | 0.778 | −0.721 |
| 10 | Trichostatin A | 100 nM | MCF7 | 0.969 | 0.814 | −0.684 |
| 11 | Trichostatin A | 100 nM | MCF7 | 0.968 | 0.816 | −0.681 |
| 12 | Trichostatin A | 100 nM | MCF7 | 0.967 | 0.767 | −0.729 |
| 13 | Vorinostat | 10 μM | MCF7 | 0.966 | 0.781 | −0.714 |
| 14 | Vorinostat | 10 μM | MCF7 | 0.964 | 0.803 | −0.688 |
| 15 | Vorinostat | 10 μM | MCF7 | 0.963 | 0.791 | −0.698 |
| 16 | Trichostatin A | 1 μM | MCF7 | 0.963 | 0.801 | −0.688 |
| 17 | Vorinostat | 10 μM | MCF7 | 0.963 | 0.789 | −0.700 |
| 18 | Trichostatin A | 1 μM | MCF7 | 0.963 | 0.784 | −0.705 |
| 19 | Trichostatin A | 100 nM | MCF7 | 0.962 | 0.795 | −0.693 |
| 20 | Vorinostat | 10 μM | MCF7 | 0.961 | 0.799 | −0.686 |
The number of up‐ and down‐signatures are shown in parenthesis.