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. 2013 Jun 17;104(8):983–988. doi: 10.1111/cas.12190

Table 3.

Non‐structural protein (NSP)‐mediated viral defense against host immunity

NSP Major target Impact
p8I T‐cell antigen receptor Causes anergy; inhibits viral 5′‐LTR induction25
p12I MHC‐I Inhibits viral antigens presented to CTL38
p13II Tax Inhibits viral replication by direct binding50
p30II Tax/Rex mRNA Inhibits Tax/Rex production and viral replication46
HBZ CREB‐2 Inhibits viral transcription by Tax51

CREB, CRE‐binding protein; CTL, cytotoxic T‐lymphocytes; HBZ, HTLV‐1 bZIP factor; LTR, long terminal repeat; MHC‐I, major histocompatibility complex class I.