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. 2013 Jun 13;104(8):1120–1126. doi: 10.1111/cas.12194

Figure 4.

Figure 4

Effects of protein tyrosine kinase 7 (PTK7) knockdown on oncogenic properties of esophageal squamous cell carcinoma (ESCC) cell lines. The ESCC cells were infected with lentivirus harboring a puromycin resistance gene (control vs shRNA‐PTK7‐6433 vs shRNA‐PTK7‐6434) and mixed cultures of puromycin‐resistant colonies were used. (a) Effect of PTK7 knockdown on cell proliferation in TE‐10 (left panel) and TE‐11 (right panel) cells. (b) Effect of PTK7 knockdown on cell survival of 5‐fluorouracil (5‐FU)‐treated TE‐10 ESCC cells. (c) Effect of PTK7 knockdown on wound healing in TE‐10 ESCC cells. Light micrographs (×100) showing wound healing in monolayers of TE‐10 cells with or without PTK7 knockdown. (d) Effect of PTK7 knockdown on Matrigel invasion of TE‐10 ESCC cells. *P < 0.05; **P < 0.01; ***P < 0.001 vs control.